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1

1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines

Richard F.G. Fröhlich, Richard H. Furneaux, Don J. Mahuran, Brigitte A. Rigat, Arnold E. Stütz, Michael B. Tropak, Jacqueline Wicki, Stephen G. Withers, Tanja M. Wrodnigg

Journal:

Carbohydrate Research

Année:

2010

Langue:

english

Fichier:

PDF, 480 KB

english, 2010

2

1-Deoxy-d-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines

Richard F.G. Fröhlich, Richard H. Furneaux, Don J. Mahuran, Robert Saf, Arnold E. Stütz, Michael B. Tropak, Jacqueline Wicki, Stephen G. Withers, Tanja M. Wrodnigg

Journal:

Carbohydrate Research

Année:

2011

Langue:

english

Fichier:

PDF, 598 KB

english, 2011

3

Remote Preconditioning Improves Maximal Performance in Highly Trained Athletes

JEAN-ST-MICHEL, EMILIE, MANLHIOT, CEDRIC, LI, JING, TROPAK, MICHAEL, MICHELSEN, MARIE M., SCHMIDT, MICHAEL R., MCCRINDLE, BRIAN W., WELLS, GREG D., REDINGTON, ANDREW N.

Journal:

Medicine & Science in Sports & Exercise

Année:

2011

Langue:

english

Fichier:

PDF, 7.58 MB

english, 2011

4

Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications

Brian P. Rempel, Dr. Michael B. Tropak, Dr. Don J. Mahuran, Prof. Stephen G. Withers

Journal:

Angewandte Chemie

Année:

2011

Langue:

english

Fichier:

PDF, 372 KB

english, 2011

5

Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications

Brian P. Rempel, Dr. Michael B. Tropak, Dr. Don J. Mahuran, Prof. Stephen G. Withers

Journal:

Angewandte Chemie International Edition

Année:

2011

Langue:

english

Fichier:

PDF, 355 KB

english, 2011

6

Isofagomine Induced Stabilization of Glucocerebrosidase

Gregory J. Kornhaber, Michael B. Tropak, Gustavo H. Maegawa, Steven J. Tuske, Stephen J. Coales, Don J. Mahuran, Yoshitomo Hamuro

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 892 KB

english, 2008

7

Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry

Michael B. Tropak, Gregory J. Kornhaber, Brigitte A. Rigat, Gustavo H. Maegawa, Justin D. Buttner, Jan E. Blanchard, Cecilia Murphy, Steven J. Tuske, Stephen J. Coales, Yoshitomo Hamuro, Eric D. Brown

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2008

8

Cover Picture: Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry (ChemBioChem 16/2008)

Michael B. Tropak, Gregory J. Kornhaber, Brigitte A. Rigat, Gustavo H. Maegawa, Justin D. Buttner, Jan E. Blanchard, Cecilia Murphy, Steven J. Tuske, Stephen J. Coales, Yoshitomo Hamuro, Eric D. Brown

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2008

9

Synthesis, Kinetic Evaluation and Cell-Based Analysis of C-Alkylated Isofagomines as Chaperones of β-Glucocerebrosidase

Tara Hill, Dr. Michael B. Tropak, Dr. Don Mahuran, Dr. Stephen G. Withers

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 256 KB

english, 2011

10

Identification of drug candidates which increase cytochrome c oxidase activity in deficient patient fibroblasts

Mary Maj, Niroshan Sriskandarajah, Vinci Hung, Ikennah Browne, Bhavank Shah, Anita Weadge, Nicola L. Jamieson, Michael Tropak, Jessie M. Cameron, Jane B. Addis, Brian H. Robinson

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2011

11

1-Deoxygalactonojirimycin-lysine hybrids as potent d-galactosidase inhibitors

Andreas J. Steiner, Georg Schitter, Arnold E. Stütz, Tanja M. Wrodnigg, Chris A. Tarling, Stephen G. Withers, Katrin Fantur, Don Mahuran, Eduard Paschke, Michael Tropak

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 191 KB

english, 2008

12

High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones

Michael B. Tropak, Jan E. Blanchard, Stephen G. Withers, Eric D. Brown, Don Mahuran

Journal:

Chemistry & Biology

Année:

2007

Langue:

english

Fichier:

PDF, 714 KB

english, 2007

13

2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors

Andreas J. Steiner, Georg Schitter, Arnold E. Stütz, Tanja M. Wrodnigg, Chris A. Tarling, Stephen G. Withers, Don J. Mahuran, Michael B. Tropak

Journal:

Tetrahedron: Asymmetry

Année:

2009

Langue:

english

Fichier:

PDF, 342 KB

english, 2009

14

High-Resolution Mapping of GenS3 and B11F7 Epitopes on Myelin-Associated Glycoprotein by Expression PCR

Michael B. Tropak, John C. Roder

Journal:

Journal of Neurochemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1994

15

Comparison of HCMV IE and EF-1 Promoters for the Stable Expression of β-Subunit of Hexosaminidase in CHO Cell Lines

Incilay Sinici, Maryam Zarghooni, Michael B. Tropak, Don J. Mahuran, H. Asuman Özkara

Journal:

Biochemical Genetics

Année:

2006

Langue:

english

Fichier:

PDF, 214 KB

english, 2006

16

Lending a helping hand, screening chemical libraries for compounds that enhance β-hexosaminidase A activity in GM2 gangliosidosis cells

Michael B. Tropak, Don Mahuran

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 516 KB

english, 2007

17

MyeliN-associated Glycoprotein Binding to Gangliosides: Structural Specificity and Functional Implications

RONALD L. SCHNAAR, BRIAN E. COLLINS, LATASHA P. WRIGHT, MAKOTO KISO, MICHAEL B. TROPAK, JOHN C. RODER, PAUL R. CROCKER

Journal:

Annals of the New York Academy of Sciences

Année:

1998

Fichier:

PDF, 2.16 MB

1998

18

Myelination in the absence of myelin-associated glycoprotein

Li, Chumei, Tropak, Michael B., Gerlai, Robert, Clapoff, Susan, Abramow-Newerly, Wanda, Trapp, Bruce, Peterson, Alan, Roder, John

Journal:

Année:

1994

Fichier:

PDF, 700 KB

1994

19

Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors

Kathrine L. Redington, Tara Disenhouse, Samuel C. Strantzas, Rachel Gladstone, Can Wei, Michael B. Tropak, Xiaojing Dai, Cedric Manlhiot, Jing Li, Andrew N. Redington

Journal:

Basic Research in Cardiology

Année:

2012

Langue:

english

Fichier:

PDF, 632 KB

english, 2012

20

Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocardial performance after neonatal cardioplegic arrest

Lixing Wang, Norihiko Oka, Michael Tropak, John Callahan, John Lee, Greg Wilson, Andrew Redington, Christopher A. Caldarone

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Année:

2008

Langue:

english

Fichier:

PDF, 742 KB

english, 2008

21

Potent neuroprotection induced by remote preconditioning in a rat model of neonatal cerebral hypoxic–ischemic injury

Michael B. Tropak, Hui Shi, Jing Li, XiaoJing Dai, Andrew N. Redington, Rand Askalan

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Année:

2011

Langue:

english

Fichier:

PDF, 392 KB

english, 2011

22

Cloning of cDNA encoding the membrane-bound form of bovine β1,4-galactosyltransferase

Giacomo D'AGOSTARO, Brad BENDIAK, Michael TROPAK

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 828 KB

english, 1989

23

Cloning and Molecular Characterization of Two Splice Variants of a New Putative Member of the Siglec-3-like Subgroup of Siglecs

George Foussias, Steve M. Taylor, George M. Yousef, Michael B. Tropak, Michael H. Ordon, Eleftherios P. Diamandis

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 376 KB

english, 2001

24

Cytotoxicity of B72.3XOKT3 Bispecific Antibody Recognizing Human Colon Cancer

Baruch Shpitz, Hartley Stern, Jas S. Sandhu, Raymond M. Reilley, Michael B. Tropak, Gwen Jansz, Jennis Xu, Steven Gallinger

Journal:

Journal of Surgical Research

Année:

1996

Langue:

english

Fichier:

PDF, 119 KB

english, 1996

25

Conservation of functionally important epitopes on myelin associated glycoprotein (MAG)

Michael B. Tropak, Gwenderlyn F. Jansz, Wanda Abramow-Newerly, John C. Roder

Journal:

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Année:

1995

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1995

26

An α-subunit loop structure is required for GM2 activator protein binding by β-hexosaminidase A

Maryam Zarghooni, Scott Bukovac, Michael Tropak, John Callahan, Don Mahuran

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 284 KB

english, 2004

27

7 Identification of the gene encoding the enzyme deficient in MPS IIIC (Sanfilippo disease type C)

Xiaolian Fan, Huiwen Zhang, Sunqu Zhang, Richard Bagshaw, Michael Tropak, John Callahan, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 57 KB

english, 2007

28

19 Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis

Don Mahuran, Gustavo Maegawa, Michael Tropak, Joe Clarke

Journal:

Molecular Genetics and Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 56 KB

english, 2007

29

65. Identification of Ambroxol as a potential enzyme enhancement-agent for Gaucher disease

Don Mahuran, Gustavo Maegawa, Michael Tropak, Justin Butner, Gregory Kornhaber, Brigitte Rigat, Joe Clarke

Journal:

Molecular Genetics and Metabolism

Année:

2008

Langue:

english

Fichier:

PDF, 43 KB

english, 2008

30

100. Effects of novel β-glucocerebrosidase enhancers and pharmacological chaperones on protein stability/dynamics probed by hydrogen–deuterium exchange mass spectrometry

Michael Tropak, Greg Kornhaber, Gustavo Maegawa, Justin Buttner, Jan Blancharrd, Brigitte Rigat, Eric Brown, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Année:

2008

Langue:

english

Fichier:

PDF, 44 KB

english, 2008

31

116. Identification of pharmacological chaperones for feline and human GM1 gangliosidosis

Brigitte Rigat, Tropak Michael, Ellen Crushell, Benedict Daphne, Douglas Martin, Arnold Stuetz, John Callahan, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Année:

2009

Langue:

english

Fichier:

PDF, 55 KB

english, 2009

32

30. Open-label Phase I/II clinical trial of pyrimethamine for the treatment of chronic GM2 gangliosidosis

Joe Clarke, Edwin Kolodny, Don Mahuran, Maria Fuller, Michael Tropak, Jack Keimel, Swati Sathe, Sophia Pesotchinsky, Brigette Rigat

Journal:

Molecular Genetics and Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 43 KB

english, 2010

33

119. Widening of in vitro spectrum of activity for pyrimethamine and its most active derivative in adult Tay-Sachs disease

Brigitte Rigat, Michael Tropak, Sayuri Yonekawa, Marco Ciufolini, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 44 KB

english, 2010

34

89. Demonstration of the in cellulo efficacy of pyrimethamine as a pharmacological chaperone for late onset Tay-Sachs Disease using a fluorescent GM2 ganglioside analogue

Don Mahuran, Michael Tropak, Scott Bukovac, Brigitte Rigat, Sayuri Yonekawa, Warren Wakarchuk

Journal:

Molecular Genetics and Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 42 KB

english, 2010

35

135. Identification of pyrimethamine derivatives showing improved enzyme enhancement efficacy towards mutant Hex A

Michael Tropak, Sayuri Yonekawa, Jianmin Zhang, Kam Ho, Virender Aulakh, Marco Ciufolini, Don Mahuran

Journal:

Molecular Genetics and Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 42 KB

english, 2010

36

An open-label Phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 gangliosidosis (Tay–Sachs or Sandhoff variants)

Joe T.R. Clarke, Don J. Mahuran, Swati Sathe, Edwin H. Kolodny, Brigitte A. Rigat, Julian A. Raiman, Michael B. Tropak

Journal:

Molecular Genetics and Metabolism

Année:

2011

Langue:

english

Fichier:

PDF, 340 KB

english, 2011

37

An open-label phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 Gangliosidosis (Tay-Sachs or Sandhoff variants)

Joe Clarke, Don Mahuran, Swati Sathe, Edwin Kolodny, Brigitte Rigat, Julian Raiman, Michael Tropak

Journal:

Molecular Genetics and Metabolism

Année:

2011

Langue:

english

Fichier:

PDF, 56 KB

english, 2011

38

Pharmacological chaperones facilitate the post-ER transport of recombinant N370S mutant β-glucocerebrosidase in plant cells: Evidence that N370S is a folding mutant

Gholamreza Babajani, Michael B. Tropak, Don J. Mahuran, Allison R. Kermode

Journal:

Molecular Genetics and Metabolism

Année:

2012

Langue:

english

Fichier:

PDF, 493 KB

english, 2012

39

Identification of the Gene Encoding the Enzyme Deficient in Mucopolysaccharidosis IIIC (Sanfilippo Disease Type C)

Xiaolian Fan, Huiwen Zhang, Sunqu Zhang, Richard D. Bagshaw, Michael B. Tropak, John W. Callahan, Don J. Mahuran

Journal:

The American Journal of Human Genetics

Année:

2006

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2006

40

Evaluation of N-nonyl-deoxygalactonojirimycin as a pharmacological chaperone for human GM1 gangliosidosis leads to identification of a feline model suitable for testing enzyme enhancement therapy

Brigitte A. Rigat, Michael B. Tropak, Justin Buttner, Ellen Crushell, Daphne Benedict, John W. Callahan, Douglas R. Martin, Don J. Mahuran

Journal:

Molecular Genetics and Metabolism

Année:

2012

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2012

41

Rapid Assembly of a Library of Lipophilic Iminosugars via the Thiol–Ene Reaction Yields Promising Pharmacological Chaperones for the Treatment of Gaucher Disease

Goddard-Borger, Ethan D., Tropak, Michael B., Yonekawa, Sayuri, Tysoe, Christina, Mahuran, Don J., Withers, Stephen G.

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2012

42

Interaction of δ and κ opioid receptors with adenosine A1 receptors mediates cardioprotection by remote ischemic preconditioning

Surendra, Harinee, Diaz, Roberto J., Harvey, Kordan, Tropak, Michael, Callahan, John, Hinek, Alina, Hossain, Taneya, Redington, Andrew, Wilson, Gregory J.

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2013

Langue:

english

Fichier:

PDF, 686 KB

english, 2013

43

Remote Cardioprotection by Transfer of Coronary Effluent from Ischemic Preconditioned Rabbit Heart Preserves Mitochondrial Integrity and Function via Adenosine Receptor Activation

Leung, Chung Ho, Wang, Lixing, Nielsen, Jan M., Tropak, Michael B., Fu, Yana Y., Kato, Hideyuki, Callahan, John, Redington, Andrew N., Caldarone, Christopher A.

Journal:

Cardiovascular Drugs and Therapy

Année:

2014

Langue:

english

Fichier:

PDF, 341 KB

english, 2014

44

Molecular characterization of the schwann cell myelin protein, SMP: Structural similarities within the immunoglobulin superfamily

Dulac, Catherine, Tropak, Michael B., Cameron-Curry, Patrizia, Rossier, Jean, Marshak, Daniel R., Roder, John, Le Douarin, Nicole M.

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 5.49 MB

english, 1992

45

Transcutaneous electrical nerve stimulation as a novel method of remote preconditioning: in vitro validation in an animal model and first human observations

Merlocco, Anthony C., Redington, Kathrine L., Disenhouse, Tara, Strantzas, Samuel C., Gladstone, Rachel, Wei, Can, Tropak, Michael B., Manlhiot, Cedric, Li, Jing, Redington, Andrew N.

Journal:

Basic Research in Cardiology

Année:

2014

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2014

46

Mutations in the rplJ leader of Escherichia coli that abolish feedback regulation

Friesen, James D., Tropak, Michael, An, Gynheung

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 964 KB

english, 1983

47

Differential splicing of MAG transcripts during CNS and PNS development

Tropak, Michael B., Johnson, Paul W., Dunn, Robert J., Roder, John C.

Journal:

Molecular Brain Research

Année:

1988

Langue:

english

Fichier:

PDF, 1.31 MB

english, 1988

48

Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function

Johnson, Paul W., Abramow-Newerly, Wanda, Seilheimer, Bernd, Sadoul, Remy, Tropak, Michael B., Arquint, Monique, Dunn, Robert J., Schachner, Melitta, Roder, John C.

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 4.92 MB

english, 1989

49

Synthesis of 1,5-Dideoxy-1,5-iminoribitol C -Glycosides through a Nitrone–Olefin Cycloaddition Domino Strategy: Identification of Pharmacological Chaperones of Mutant Human Lysosomal β-Galactosidase

Siriwardena, Aloysius, Sonawane, Dhiraj P., Bande, Omprakash P., Markad, Pramod R., Yonekawa, Sayuri, Tropak, Michael B., Ghosh, Sougata, Chopade, Balu A., Mahuran, Don J., Dhavale, Dilip D.

Journal:

Journal of Organic Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 562 KB

english, 2014

50

Cloning, Sequencing, and Expression of cDNA for Human β -glucuronidase

Akihiro Oshima, John W. Kyle, Raymond D. Miller, Joseph W. Hoffmann, Penelope P. Powell, Jeffrey H. Grubb, William S. Sly, Michael Tropak, Kevin S. Guise and Roy A. Gravel

Journal:

Proceedings of the National Academy of Sciences

Année:

1987

Langue:

english

Fichier:

PDF, 942 KB

english, 1987